Apply 1 pump (0.25mg Estradiol) to smooth skin areas such as wrists, inner arms or thighs, neck, abdomen, and chest once or twice daily, or as directed by your healthcare practitioner. These are general recommendations only and may be modified for individual needs. Do not use if pregnant, planning to become pregnant, or breastfeeding. For External Use Only. Do not use around the eye area. Keep out of reach of children.