The suggested use is 6 capsules a day or as directed by a healthcare professional — for added support, the dose can be doubled. If consuming more than six capsules at once, the doses should be separated by at least three hours to improve tolerability.
FOR HISTAMINE SUPPORT (DAO)
Take 10 minutes before histamine-rich foods.
Suggested use is 1-3 capsules per meal or as directed by a healthcare professional.
Start with just 1 capsule; slowly work up to therapeutic dose (see "Potential Issues" below).
NOTE: Diamine oxidate (DAO) is not an animal class nor species exclusive enzyme. In other words, DAO is not exclusive to porcine kidney nor green pea sprouts nor human placenta. In mammals, histamine can be inactivated either by methylation of the imidazole ring nitrogen, catalysed by histamine N-methyltransferase or by oxidative deamination of the primary amino group, catalysed by DAO. For these reasons, certain glands such as Kidney, Thymus, Intestines (probably placenta) that support methylation (w/ endogenous methyl groups, B12, folate, selenium, etc) and contain the DAO enzyme should be considered to support histamine health. Additionally, many legumes (lentils, beans, peas, etc) produce diamine oxidase (DAO) too as the seed germinates to form a seedling.
A detoxification reaction is more likely to occur when starting with the full suggested serving size of 6 capsules per day. If you know that you are sensitive to supplements and/or you have an autoimmune condition, you may wish to start slow when adding this product to your current regimen. Tolerability can be greatly improved by starting with just 1 (or) 2 capsules a day and increasing by just 1 capsule every couple of days — this method may take a full two weeks to achieve the desired serving size of 6 capsules per day.
For customers that are highly sensitive to supplements and/or have an autoimmune and/or methylation SNPs, I suggest that you "play it safe" by introducing just one new capsule per week. In other words, just 1 capsule during the 1st week... 2 capsules during the 2nd week... 3 capsules during the 3rd week and so on... yes, this will take some time to reach the suggested dosages but this greatly helps to ensure tolerability of this deep nourishment so that it has a chance to do good.